2j0a
From Proteopedia
STRUCTURE OF THE CATALYTIC DOMAIN OF MOUSE MANIC FRINGE
Overview
Fringe proteins are beta1,3-N-acetylglucosaminyltransferases that modify Notch receptors, altering their ligand-binding specificity to regulate Notch signaling in development. We present the crystal structure of mouse Manic Fringe bound to UDP and manganese. The structure reveals amino acid residues involved in recognition of donor substrates and catalysis, and a putative binding pocket for acceptor substrates. Mutations of several invariant residues in this pocket impair Fringe activity in vivo.
About this Structure
2J0A is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.
Reference
Structural insights into the Notch-modifying glycosyltransferase Fringe., Jinek M, Chen YW, Clausen H, Cohen SM, Conti E, Nat Struct Mol Biol. 2006 Oct;13(10):945-6. Epub 2006 Sep 10. PMID:16964258 Page seeded by OCA on Sun May 4 08:09:28 2008
Categories: Mus musculus | O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase | Single protein | Chen, Y W. | Clausen, H. | Cohen, S M. | Conti, E. | Jinek, M. | Developmental protein | Glycoprotein | Glycosyltransferase | Golgi apparatus | Membrane | Notch signaling | Signal-anchor | Transferase | Transmembrane
