3cbs
From Proteopedia
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CELLULAR RETINOIC ACID BINDING PROTEIN II IN COMPLEX WITH A SYNTHETIC RETINOIC ACID (RO-12 7310)
Overview
Retinoids play important roles in diverse cellular processes including, growth, cell differentiation and vision. Many natural and synthetic, retinoids are used as drugs in dermatology and oncology. A large amount of, data has been accumulated on the cellular activity of different synthetic, retinoids. They are stabilized and transported inside the cell cytoplasm, by binding and transport proteins, such as cellular retinol-binding, proteins and cellular retinoic acid binding proteins (CRABPs). The, structures of human CRABP II in complex with two different synthetic, retinoids, Ro13-6307 and Ro12--7310 (at 2.1 and 2.0 A resolution, respectively) and of bovine CRABP I in complex with a retinobenzoic acid, Am80 (at 2.8 A resolution) are described. The binding affinities of human, CRABP I and II for the retinoids studied here have been determined. All, these compounds have comparable binding affinities (nanomolar range) for, both CRABPs. Apart from the particular interactions of the carboxylate, group of the retinoids with specific protein groups, each structure, reveals characteristic interactions. Studying the atomic details of the, interaction of retinoids with retinoid-binding proteins facilitates the, understanding of the kinetics of retinoid trafficking inside the, cytoplasm.
About this Structure
3CBS is a Single protein structure of sequence from Homo sapiens with R12 as ligand. Full crystallographic information is available from OCA.
Reference
Structures of cellular retinoic acid binding proteins I and II in complex with synthetic retinoids., Chaudhuri BN, Kleywegt GJ, Broutin-L'Hermite I, Bergfors T, Senn H, Le Motte P, Partouche O, Jones TA, Acta Crystallogr D Biol Crystallogr. 1999 Nov;55(Pt 11):1850-7. PMID:10531482
Page seeded by OCA on Mon Nov 12 23:47:51 2007
