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4gr1

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Image:4gr1.gif

4gr1, resolution 2.4Å

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THE BINDING OF THE RETRO-ANALOGUE OF GLUTATHIONE DISULFIDE TO GLUTATHIONE REDUCTASE

Contents

Overview

The retro-analogue of glutathione disulfide was bound to the GSSG binding, site of crystalline glutathione reductase. The binding mode revealed why, the analogue is a very poor substrate in enzyme catalysis. The observed, binding mode difference between natural substrate and retro-analogue is, explained.

Disease

Known disease associated with this structure: Hemolytic anemia due to glutathione reductase deficiency OMIM:[138300]

About this Structure

4GR1 is a Single protein structure of sequence from Homo sapiens with PO4, FAD and RGS as ligands. Active as Glutathione-disulfide reductase, with EC number 1.8.1.7 Full crystallographic information is available from OCA.

Reference

The binding of the retro-analogue of glutathione disulfide to glutathione reductase., Janes W, Schulz GE, J Biol Chem. 1990 Jun 25;265(18):10443-5. PMID:2355009

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