2bhs
From Proteopedia
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CRYSTAL STRUCTURE OF CYSTEINE SYNTHASE B
Overview
The enzyme O-acetylserine sulfhydrylase participates in the biosynthesis, of l-cysteine in bacteria and plants. The structure of isoenzyme B (CysM), from Escherichia coli was established in a hexagonal crystal form at 2.7 A, resolution (wild-type) and in a merohedrally twinned tetragonal crystal, form at 2.1 A resolution (surface mutant). Structural superpositions, revealed the variations with respect to isoenzyme A (CysK) and explained, the different substrate specificities. A geometric model of the reaction, catalyzed by CysM is proposed. Both isoenzymes are used for the production, of l-amino acid derivatives as building blocks for the synthesis of, peptides and peptidomimetic drugs. Since the structure of CysM revealed a, remarkable main chain variation at the active center, it ... [(full description)]
About this Structure
2BHS is a [Single protein] structure of sequence from [Escherichia coli] with PLP as [ligand]. Active as [[1]], with EC number [2.5.1.47]. Full crystallographic information is available from [OCA].
Reference
Structure of the O-acetylserine sulfhydrylase isoenzyme CysM from Escherichia coli., Claus MT, Zocher GE, Maier TH, Schulz GE, Biochemistry. 2005 Jun 21;44(24):8620-6. PMID:15952768
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