2nqc
From Proteopedia
| |||||||||
| 2nqc, resolution 2.05Å () | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Ligands: | , , | ||||||||
| |||||||||
| |||||||||
| Resources: | FirstGlance, OCA, RCSB, PDBsum | ||||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||||
Crystal structure of ig-like domain 23 from human filamin C
Overview
Filamin C is a dimeric, actin-binding protein involved in organization of cortical cytoskeleton and of the sarcomere. We performed crystallographic, small-angle X-ray scattering and analytical ultracentrifugation experiments on the constructs containing carboxy-terminal domains of the protein (domains 23-24 and 19-21). The crystal structure of domain 23 of filamin C showed that the protein adopts the expected immunoglobulin (Ig)-like fold. Small-angle X-ray scattering experiments performed on filamin C tandem Ig-like domains 23 and 24 reveal a dimer that is formed by domain 24 and that domain 23 has little interactions with itself or with domain 24, while the analytical ultracentrifugation experiments showed that the filamin C domains 19-21 form elongated monomers in diluted solutions.
About this Structure
2NQC is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Crystal structure of human filamin C domain 23 and small angle scattering model for filamin C 23-24 dimer., Sjekloca L, Pudas R, Sjoblom B, Konarev P, Carugo O, Rybin V, Kiema TR, Svergun D, Ylanne J, Djinovic Carugo K, J Mol Biol. 2007 May 11;368(4):1011-23. Epub 2007 Feb 20. PMID:17379241 Page seeded by OCA on Sun May 4 09:46:43 2008
