1got

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Image:1got.gif

1got, resolution 2.0Å

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HETEROTRIMERIC COMPLEX OF A GT-ALPHA/GI-ALPHA CHIMERA AND THE GT-BETA-GAMMA SUBUNITS

Overview

The structure of a heterotrimeric G protein reveals the mechanism of the, nucleotide-dependent engagement of the alpha and beta gamma subunits that, regulates their interaction with receptor and effector molecules. The, interaction involves two distinct interfaces and dramatically alters the, conformation of the alpha but not of the beta gamma subunits. The location, of the known sites for post-translational modification and receptor, coupling suggest a plausible orientation with respect to the membrane, surface and an activated heptahelical receptor.

About this Structure

1GOT is a Protein complex structure of sequences from Bos taurus with GDP as ligand. The following page contains interesting information on the relation of 1GOT with [G Proteins]. Full crystallographic information is available from OCA.

Reference

The 2.0 A crystal structure of a heterotrimeric G protein., Lambright DG, Sondek J, Bohm A, Skiba NP, Hamm HE, Sigler PB, Nature. 1996 Jan 25;379(6563):311-9. PMID:8552184

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