1h8l
From Proteopedia
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DUCK CARBOXYPEPTIDASE D DOMAIN II IN COMPLEX WITH GEMSA
Overview
The three-dimensional crystal structure of duck carboxypeptidase D domain, II has been solved in a complex with the peptidomimetic inhibitor, guanidinoethylmercaptosuccinic acid, occupying the specificity pocket., This structure allows a clear definition of the substrate binding sites, and the substrate funnel-like access. The structure of domain II is the, only one available from the regulatory carboxypeptidase family and can be, used as a general template for its members. Here, it has been used to, model the structures of domains I and III from the former protein and of, human carboxypeptidase E. The models obtained show that the overall, topology is similar in all cases, the main differences being local and, because of insertions in non-regular loops. In both carboxypeptidase D, domain ... [(full description)]
About this Structure
1H8L is a [Single protein] structure of sequence from [Lophonetta specularioides] with NAG, SO4, ZN and GEM as [ligands]. Full crystallographic information is available from [OCA].
Reference
The crystal structure of the inhibitor-complexed carboxypeptidase D domain II and the modeling of regulatory carboxypeptidases., Aloy P, Companys V, Vendrell J, Aviles FX, Fricker LD, Coll M, Gomis-Ruth FX, J Biol Chem. 2001 May 11;276(19):16177-84. Epub 2001 Feb 14. PMID:11278909
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