1yso
From Proteopedia
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YEAST CU, ZN SUPEROXIDE DISMUTASE WITH THE REDUCED BRIDGE BROKEN
Overview
The three-dimensional structure of yeast copper-zinc superoxide dismutase, (CuZnSOD) has been determined in a new crystal form in space group R32 and, refined against X-ray diffraction data using difference Fourier and, restrained crystallographic refinement techniques. The unexpected result, is that the copper ion has moved approximately 1 angstrom from its, position in previously reported CuZnSOD models, the copper-imidazolate, bridge is broken, and a roughly trigonal planar ligand geometry, characteristic of Cu(I) rather than Cu(II) is revealed. Final R values for, the two nearly identical room temperature structures are 18.6% for all 19, 149 reflections in the 10.0-1.7 angstrom resolution range and 18. 2% for, 17 682 reflections (F > 2 sigma) in the 10.0-1.73 angstrom resolution, ... [(full description)]
About this Structure
1YSO is a [Single protein] structure of sequence from [Candida albicans] with CU1 and ZN as [ligands]. Active as [[1]], with EC number [1.15.1.1]. Full crystallographic information is available from [OCA].
Reference
Unusual trigonal-planar copper configuration revealed in the atomic structure of yeast copper-zinc superoxide dismutase., Ogihara NL, Parge HE, Hart PJ, Weiss MS, Goto JJ, Crane BR, Tsang J, Slater K, Roe JA, Valentine JS, Eisenberg D, Tainer JA, Biochemistry. 1996 Feb 20;35(7):2316-21. PMID:8652572
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