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1mco
From Proteopedia
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THREE-DIMENSIONAL STRUCTURE OF A HUMAN IMMUNOGLOBULIN WITH A HINGE DELETION
Overview
X-ray analysis at 3.2-A resolution revealed that the Mcg IgG1 (lambda, chain) immunoglobulin is a compact T-shaped molecule. Because of the hinge, deletion, the Fc fragment lobe is pulled tightly upward into the junction, of the Fab arms. Along the molecular twofold axis, the Fab arms are joined, by an interchain disulfide bond between the two light chains. The antigen, combining sites consist of large irregular cavities at the tips of the Fab, regions. Potential complement (C1q) binding sites on Fc are sterically, shielded by the Fab arms, but putative attachment sites are accessible for, docking with the FcRI receptor on human monocytes and with protein A of, Staphylococcus aureus.
About this Structure
1MCO is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Three-dimensional structure of a human immunoglobulin with a hinge deletion., Guddat LW, Herron JN, Edmundson AB, Proc Natl Acad Sci U S A. 1993 May 1;90(9):4271-5. PMID:8483943
Page seeded by OCA on Sun Nov 18 09:36:17 2007
