1o87

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spinqualitylabelsall models 1o87, resolution 2.10Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

A NEW MGGDP COMPLEX OF THE FFH NG DOMAIN

Overview

Ffh is the signal sequence recognition and targeting subunit of the, prokaryotic signal recognition particle (SRP). Previous structural studies, of the NG GTPase domain of Ffh demonstrated magnesium-dependent and, magnesium-independent binding conformations for GDP and GMPPNP that are, believed to reflect novel mechanisms for exchange and activation in this, member of the GTPase superfamily. The current study of the NG GTPase bound, to Mg(2+)GDP reveals two new binding conformations-in the first the, magnesium interactions are similar to those seen previously, however, the, protein undergoes a conformational change that brings a conserved, aspartate into its second coordination sphere. In the second, the protein, conformation is similar to that seen previously, but the magnesium, ... [(full description)]

About this Structure

1O87 is a [Single protein] structure of sequence from [Thermus aquaticus] with CL, MG, GDP and FMT as [ligands]. Full crystallographic information is available from [OCA].

Reference

Novel protein and Mg2+ configurations in the Mg2+GDP complex of the SRP GTPase ffh., Focia PJ, Alam H, Lu T, Ramirez UD, Freymann DM, Proteins. 2004 Feb 1;54(2):222-30. PMID:14696184

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