1aft

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1aft

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SMALL SUBUNIT C-TERMINAL INHIBITORY PEPTIDE OF MOUSE RIBONUCLEOTIDE REDUCTASE AS BOUND TO THE LARGE SUBUNIT, NMR, 26 STRUCTURES

Overview

The structure of peptide N-AcYTLDADF when bound to the large subunit of, mouse ribonucleotide reductase has been elucidated by transfer NOE. This, structure suggests a general design for type 1 RR inhibitors.

About this Structure

1AFT is a Single protein structure of sequence from [1] with ACE as ligand. Active as Ribonucleoside-diphosphate reductase, with EC number 1.17.4.1 Full crystallographic information is available from OCA.

Reference

NMR structure of an inhibitory R2 C-terminal peptide bound to mouse ribonucleotide reductase R1 subunit., Fisher A, Laub PB, Cooperman BS, Nat Struct Biol. 1995 Nov;2(11):951-5. PMID:7583667

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