1agq

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Image:1agq.gif

1agq, resolution 1.90Å

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GLIAL CELL-DERIVED NEUROTROPHIC FACTOR FROM RAT

Overview

The crystal structure of glial cell-derived neurotrophic factor (GDNF), reveals two independent copies of the dimer that differ significantly, through a hinge bending at the central, disulphide-rich region. GDNF is, compared with other members of the TGF-beta family, and potential receptor, binding surfaces are identified.

About this Structure

1AGQ is a Single protein structure of sequence from Rattus norvegicus. Full crystallographic information is available from OCA.

Reference

X-ray structure of glial cell-derived neurotrophic factor at 1.9 A resolution and implications for receptor binding., Eigenbrot C, Gerber N, Nat Struct Biol. 1997 Jun;4(6):435-8. PMID:9187648

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