1ah8

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spinqualitylabelsall models 1ah8, resolution 2.10Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

STRUCTURE OF THE ORTHORHOMBIC FORM OF THE N-TERMINAL DOMAIN OF THE YEAST HSP90 CHAPERONE

Overview

Hsp90 is a highly specific chaperone for many signal transduction, proteins, including steroid hormone receptors and a broad range of protein, kinases. The crystal structure of the N-terminal domain of the yeast Hsp90, reveals a dimeric structure based on a highly twisted sixteen stranded, beta-sheet, whose topology suggests a possible 30-domain-swapped structure, for the intact Hsp90 dimer. The opposing faces of the beta-sheets in the, dimer define a potential peptide-binding cleft, suggesting that the, N-domain may serve as a molecular 'clamp' in the binding of ligand, proteins to Hsp90.

About this Structure

1AH8 is a Single protein structure of sequence from Saccharomyces cerevisiae with GOL as ligand. Full crystallographic information is available from OCA.

Reference

A molecular clamp in the crystal structure of the N-terminal domain of the yeast Hsp90 chaperone., Prodromou C, Roe SM, Piper PW, Pearl LH, Nat Struct Biol. 1997 Jun;4(6):477-82. PMID:9187656

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