3bch

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Image:3bch.jpg

Template:STRUCTURE 3bch

Crystal Structure of the Human Laminin Receptor Precursor


Overview

The human laminin receptor (LamR) interacts with many ligands, including laminin, prions, Sindbis virus, and the polyphenol (-)-epigallocatechin-3-gallate (EGCG), and has been implicated in a number of diseases. LamR is overexpressed on tumor cells, and targeting LamR elicits anti-cancer effects. Here, we report the crystal structure of human LamR, which provides insights into its function and should facilitate the design of novel therapeutics targeting LamR.

About this Structure

3BCH is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of the human laminin receptor precursor., Jamieson KV, Wu J, Hubbard SR, Meruelo D, J Biol Chem. 2008 Feb 8;283(6):3002-5. Epub 2007 Dec 6. PMID:18063583 Page seeded by OCA on Sun May 4 20:38:10 2008

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