2bz1

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spinqualitylabelsall models 2bz1, resolution 1.54Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

CRYSTAL STRUCTURE OF APO E. COLI GTP CYCLOHYDROLASE II

Overview

GTP cyclohydrolase II converts GTP to, 2,5-diamino-6-beta-ribosyl-4(3H)-pyrimidinone 5'-phosphate, formate and, pyrophosphate, the first step in riboflavin biosynthesis. The essential, role of riboflavin in metabolism and the absence of GTP cyclohydrolase II, in higher eukaryotes makes it a potential novel selective antimicrobial, drug target. GTP cyclohydrolase II catalyzes a distinctive overall, reaction from GTP cyclohydrolase I; the latter converts GTP to, dihydroneopterin triphosphate, utilized in folate and tetrahydrobiopterin, biosynthesis. The structure of GTP cyclohydrolase II determined at 1.54-A, resolution reveals both a different protein fold to GTP cyclohydrolase I, and distinctive molecular recognition determinants for GTP; although in, both enzymes there is a bound ... [(full description)]

About this Structure

2BZ1 is a [Single protein] structure of sequence from [Escherichia coli] with ZN, SO4, TAU and GOL as [ligands]. Active as [[1]], with EC number [3.5.4.25]. Full crystallographic information is available from [OCA].

Reference

GTP cyclohydrolase II structure and mechanism., Ren J, Kotaka M, Lockyer M, Lamb HK, Hawkins AR, Stammers DK, J Biol Chem. 2005 Nov 4;280(44):36912-9. Epub 2005 Aug 22. PMID:16115872

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