1awc

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Image:1awc.gif

1awc, resolution 2.150Å

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MOUSE GABP ALPHA/BETA DOMAIN BOUND TO DNA

Overview

GA-binding protein (GABP) is a transcriptional regulator composed of two, structurally dissimilar subunits. The alpha subunit contains a DNA-binding, domain that is a member of the ETS family, whereas the beta subunit, contains a series of ankyrin repeats. The crystal structure of a ternary, complex containing a GABPalpha/beta ETS domain-ankyrin repeat heterodimer, bound to DNA was determined at 2. 15 angstrom resolution. The structure, shows how an ETS domain protein can recruit a partner protein using both, the ETS domain and a carboxyl-terminal extension and provides a view of an, extensive protein-protein interface formed by a set of ankyrin repeats., The structure also reveals how the GABPalpha ETS domain binds to its core, GGA DNA-recognition motif.

About this Structure

1AWC is a Protein complex structure of sequences from Mus musculus. Full crystallographic information is available from OCA.

Reference

The structure of GABPalpha/beta: an ETS domain- ankyrin repeat heterodimer bound to DNA., Batchelor AH, Piper DE, de la Brousse FC, McKnight SL, Wolberger C, Science. 1998 Feb 13;279(5353):1037-41. PMID:9461436

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