1qju

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1qju, resolution 2.8Å

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HUMAN RHINOVIRUS 16 COAT PROTEIN IN COMPLEX WITH ANTIVIRAL COMPOUND VP61209

Overview

Rhinoviruses are a frequent cause of the common cold. A series of, antirhinoviral compounds have been developed that bind into a hydrophobic, pocket in the viral capsid, stabilizing the capsid and interfering with, cell attachment. The structures of a variety of such compounds, complexed, with rhinovirus serotypes 14, 16, 1A, and 3, previously have been, examined. Three chemically similar compounds, closely related to a drug, that is undergoing phase III clinical trials, were chosen to determine the, structural impact of the heteroatoms in one of the three rings. The, compounds were found to have binding modes that depend on their electronic, distribution. In the compound with the lowest efficacy, the terminal ring, is displaced by 1 A and rotated by 180 degrees relative to the structure, ... [(full description)]

About this Structure

1QJU is a [Protein complex] structure of sequences from [[1]] with ZN, MYR and W01 as [ligands]. Full crystallographic information is available from [OCA].

Reference

Analysis of three structurally related antiviral compounds in complex with human rhinovirus 16., Hadfield AT, Diana GD, Rossmann MG, Proc Natl Acad Sci U S A. 1999 Dec 21;96(26):14730-5. PMID:10611281

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