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1b8w

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Image:1b8w.jpg

1b8w

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DEFENSIN-LIKE PEPTIDE 1

Overview

Three defensin-like peptides (DLPs) were isolated from platypus venom and, sequenced. One of these peptides, DLP-1, was synthesized chemically and, its three-dimensional structure was determined using NMR spectroscopy. The, main structural elements of this 42-residue peptide were an anti-parallel, beta-sheet comprising residues 15-18 and 37-40 and a small 3(10) helix, spanning residues 10-12. The overall three-dimensional fold is similar to, that of beta-defensin-12, and similar to the sodium-channel neurotoxin ShI, (Stichodactyla helianthus neurotoxin I). However, the side chains known to, be functionally important in beta-defensin-12 and ShI are not conserved in, DLP-1, suggesting that it has a different biological function. Consistent, with this contention, we showed that DLP-1 possesses no anti-microbial, properties and has no observable activity on rat dorsal-root-ganglion, sodium-channel currents.

About this Structure

1B8W is a Single protein structure of sequence from Ornithorhynchus anatinus. Full crystallographic information is available from OCA.

Reference

Solution structure of a defensin-like peptide from platypus venom., Torres AM, Wang X, Fletcher JI, Alewood D, Alewood PF, Smith R, Simpson RJ, Nicholson GM, Sutherland SK, Gallagher CH, King GF, Kuchel PW, Biochem J. 1999 Aug 1;341 ( Pt 3):785-94. PMID:10417345

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