1bg3

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Image:1bg3.gif

1bg3, resolution 2.8Å

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RAT BRAIN HEXOKINASE TYPE I COMPLEX WITH GLUCOSE AND INHIBITOR GLUCOSE-6-PHOSPHATE

Overview

We have determined the structures of the glucose-6-phosphate, (G6P)-inhibitable 100,000 Mr Type I hexokinase from rat and the, G6P-sensitive 50,000 Mr hexokinase from Schistosoma mansoni at a, resolution of 2.8 and 2.6 A respectively. The structures define the, glucose and G6P binding sites in these enzymes, suggest the mechanisms of, intradomain G6P inhibition and activity loss in the Type I hexokinase, N-terminal half, and reveal the structure of the membrane targeting motif, that integrates the Type I hexokinase into the outer mitochondrial, membrane.

About this Structure

1BG3 is a Single protein structure of sequence from Rattus norvegicus with GLC, G6P and CA as ligands. Active as Hexokinase, with EC number 2.7.1.1 Full crystallographic information is available from OCA.

Reference

The structure of mammalian hexokinase-1., Mulichak AM, Wilson JE, Padmanabhan K, Garavito RM, Nat Struct Biol. 1998 Jul;5(7):555-60. PMID:9665168

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