1c8z
From Proteopedia
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C-TERMINAL DOMAIN OF MOUSE BRAIN TUBBY PROTEIN
Overview
Tubby-like proteins (TULPs) are found in a broad range of multicellular, organisms. In mammals, genetic mutation of tubby or other TULPs can result, in one or more of three disease phenotypes: obesity (from which the name, "tubby" is derived), retinal degeneration, and hearing loss. These disease, phenotypes indicate a vital role for tubby proteins; however, no, biochemical function has yet been ascribed to any member of this protein, family. A structure-directed approach was employed to investigate the, biological function of these proteins. The crystal structure of the core, domain from mouse tubby was determined at a resolution of 1.9 angstroms., From primarily structural clues, experiments were devised, the results of, which suggest that TULPs are a unique family of bipartite transcription, factors.
About this Structure
1C8Z is a Single protein structure of sequence from Mus musculus with PO4 as ligand. Full crystallographic information is available from OCA.
Reference
Implication of tubby proteins as transcription factors by structure-based functional analysis., Boggon TJ, Shan WS, Santagata S, Myers SC, Shapiro L, Science. 1999 Dec 10;286(5447):2119-25. PMID:10591637
Page seeded by OCA on Tue Nov 20 12:16:13 2007
