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1c9l
From Proteopedia
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PEPTIDE-IN-GROOVE INTERACTIONS LINK TARGET PROTEINS TO THE B-PROPELLER OF CLATHRIN
Overview
The "WD40" domain is a widespread recognition module for linking partner, proteins in intracellular networks of signaling and sorting. The clathrin, amino-terminal domain, which directs incorporation of cargo into coated, pits, is a beta-propeller closely related in structure to WD40 modules., The crystallographically determined structures of complexes of the, clathrin-terminal domain with peptides derived from two different cargo, adaptors, beta-arrestin 2 and the beta-subunit of the AP-3 complex, reveal, strikingly similar peptide-in-groove interactions. The two peptides in our, structures contain related, five-residue motifs, which form the core of, their contact with clathrin. A number of other proteins involved in, endocytosis have similar "clathrin-box" motifs, and it therefore is likely, that they all bind the terminal domain in the same way. We propose that a, peptide-in-groove interaction is an important general mode by which, beta-propellers recognize specific target proteins.
About this Structure
1C9L is a Single protein structure of sequence from Rattus norvegicus. Full crystallographic information is available from OCA.
Reference
Peptide-in-groove interactions link target proteins to the beta-propeller of clathrin., ter Haar E, Harrison SC, Kirchhausen T, Proc Natl Acad Sci U S A. 2000 Feb 1;97(3):1096-100. PMID:10655490
Page seeded by OCA on Tue Nov 20 12:17:11 2007
