1cd1
From Proteopedia
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CD1(MOUSE) ANTIGEN PRESENTING MOLECULE
Overview
CD1 represents a third lineage of antigen-presenting molecules that are, distantly related to major histocompatibility complex (MHC) molecules in, the immune system. The crystal structure of mouse CD1d1, corresponding to, human CD1d, at 2.8 resolution shows that CD1 adopts an MHC fold that is, more closely related to that of MHC class I than to that of MHC class II., The binding groove, although significantly narrower, is substantially, larger because of increased depth and it has only two major pockets that, are almost completely hydrophobic. The extreme hydrophobicity and shape of, the binding site are consistent with observations that human CD1b and CD1c, can present mycobacterial cell wall antigens, such as mycolic acid and, lipoarabinomannans. However, mouse CD1d1 can present very hydrophobic, peptides, but must do so in a very different way from MHC class Ia and, class II molecules.
About this Structure
1CD1 is a Protein complex structure of sequences from Mus musculus. Full crystallographic information is available from OCA.
Reference
Crystal structure of mouse CD1: An MHC-like fold with a large hydrophobic binding groove., Zeng Z, Castano AR, Segelke BW, Stura EA, Peterson PA, Wilson IA, Science. 1997 Jul 18;277(5324):339-45. PMID:9219685
Page seeded by OCA on Tue Nov 20 12:21:33 2007
Categories: Mus musculus | Protein complex | Segelke, B.W. | Wilson, I.A. | Zeng, Z.H. | Cd1 | Glycoprotein | Immunoglobulin fold | Immunology | Mhc | Signal | T-cell | Tcr
