1cdd

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Image:1cdd.gif

1cdd, resolution 2.8Å

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STRUCTURES OF APO AND COMPLEXED ESCHERICHIA COLI GLYCINAMIDE RIBONUCLEOTIDE TRANSFORMYLASE

Overview

The three-dimensional structure of phosphoribosylglycinamide, formyltransferase (10-formyltetrahydrofolate:5'-phosphoribosylglycinamide, formyltransferase, EC 2.1.2.2) has been solved both as an apoenzyme at, 2.8-A resolution and as a ternary complex with the substrate glycinamide, ribonucleotide and a folate inhibitor at 2.5-A resolution. The structure, is a modified doubly wound alpha/beta sheet with flexibility in the active, site, including a disordered loop in the apo structure, which is ordered, in the ternary complex structure. This enzyme is a target for anti-cancer, therapy and now for structure-based drug design.

About this Structure

1CDD is a Single protein structure of sequence from Escherichia coli with PO4 as ligand. Active as Phosphoribosylglycinamide formyltransferase, with EC number 2.1.2.2 Full crystallographic information is available from OCA.

Reference

Structures of apo and complexed Escherichia coli glycinamide ribonucleotide transformylase., Almassy RJ, Janson CA, Kan CC, Hostomska Z, Proc Natl Acad Sci U S A. 1992 Jul 1;89(13):6114-8. PMID:1631098

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