1v1j

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Image:1v1j.gif

1v1j, resolution 2.2Å

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CRYSTAL STRUCTURE OF TYPE II DEHYDROQUINTAE DEHYDRATASE FROM STREPTOMYCES COELICOLOR IN COMPLEX WITH 3-FLUORO

Overview

The fluoro analogue of the enolate intermediate in the reaction catalyzed, by type II dehydroquinases has been prepared from naturally occurring, (-)-quinic acid over seven steps and has been shown to be the most potent, inhibitor reported to date of the type II enzyme from Mycobacterium, tuberculosis.

About this Structure

1V1J is a [Single protein] structure of sequence from [Streptomyces coelicolor] with FA3 and TRS as [ligands]. Active as [[1]], with EC number [4.2.1.10]. Full crystallographic information is available from [OCA].

Reference

(1R,4S,5R)-3-Fluoro-1,4,5-trihydroxy-2-cyclohexene-1-carboxylic acid: the fluoro analogue of the enolate intermediate in the reaction catalyzed by type II dehydroquinases., Frederickson M, Roszak AW, Coggins JR, Lapthorn AJ, Abell C, Org Biomol Chem. 2004 Jun 7;2(11):1592-6. Epub 2004 May 6. PMID:15162210

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