1cma

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1cma, resolution 2.800Å

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MET REPRESSOR/DNA COMPLEX + S-ADENOSYL-METHIONINE

Overview

The crystal structure of the met repressor-operator complex shows two, dimeric repressor molecules bound to adjacent sites 8 base pairs apart on, an 18-base-pair DNA fragment. Sequence specificity is achieved by, insertion of double-stranded antiparallel protein beta-ribbons into the, major groove of B-form DNA, with direct hydrogen-bonding between, amino-acid side chains and the base pairs. The repressor also recognizes, sequence-dependent distortion or flexibility of the operator phosphate, backbone, conferring specificity even for inaccessible base pairs.

About this Structure

1CMA is a Single protein structure of sequence from Escherichia coli with SAM as ligand. Full crystallographic information is available from OCA.

Reference

Crystal structure of the met repressor-operator complex at 2.8 A resolution reveals DNA recognition by beta-strands., Somers WS, Phillips SE, Nature. 1992 Oct 1;359(6394):387-93. PMID:1406951

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