2j3k
From Proteopedia
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CRYSTAL STRUCTURE OF ARABIDOPSIS THALIANA DOUBLE BOND REDUCTASE (AT5G16970)-TERNARY COMPLEX II
Overview
In this study, we determined the crystal structures of the apoform, binary, and ternary complexes of the Arabidopsis alkenal double bond, reductase encoded by At5g16970. This protein, one of 11 homologues in, Arabidopsis thaliana, is most closely related to the Pinus taeda, phenylpropenal double bond reductase, involved in, for example, heartwood, formation. Both enzymes also have essential roles in plant defense, and, can function by catalyzing the reduction of the 7-8-double bond of, phenylpropanal substrates, such as p-coumaryl and coniferyl aldehydes in, vitro. At5g16970 is also capable of reducing toxic substrates with the, same alkenal functionality, such as 4-hydroxy-(2E)-nonenal. The overall, fold of At5g16970 is similar to that of the zinc-independent medium chain, ... [(full description)]
About this Structure
2J3K is a [Single protein] structure of sequence from [[1]] with NAP and HNE as [ligands]. Active as [[2]], with EC number [1.3.1.74]. Full crystallographic information is available from [OCA].
Reference
Mechanistic and structural studies of apoform, binary, and ternary complexes of the Arabidopsis alkenal double bond reductase At5g16970., Youn B, Kim SJ, Moinuddin SG, Lee C, Bedgar DL, Harper AR, Davin LB, Lewis NG, Kang C, J Biol Chem. 2006 Dec 29;281(52):40076-88. Epub 2006 Oct 6. PMID:17028190
Page seeded by OCA on Mon Oct 29 19:32:41 2007
