1e6e

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spinqualitylabelsall models 1e6e, resolution 2.3Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

ADRENODOXIN REDUCTASE/ADRENODOXIN COMPLEX OF MITOCHONDRIAL P450 SYSTEMS

Overview

The steroid hydroxylating system of adrenal cortex mitochondria consists, of the membrane-attached NADPH-dependent adrenodoxin reductase (AR), the, soluble one-electron transport protein adrenodoxin (Adx), and a, membrane-integrated cytochrome P450 of the CYP11 family. In the 2.3-A, resolution crystal structure of the Adx.AR complex, 580 A(2) of partly, polar surface are buried. Main interaction sites are centered around, Asp(79), Asp(76), Asp(72), and Asp(39) of Adx and around Arg(211), Arg(240), Arg(244), and Lys(27) of AR, respectively. In particular, the, region around Asp(39) defines a new protein interaction site for Adx, similar to those found in plant and bacterial ferredoxins. Additional, contacts involve the electron transfer region between the redox centers of, AR and Adx and ... [(full description)]

About this Structure

1E6E is a [Protein complex] structure of sequences from [Bos taurus] with SO4, FAD and FES as [ligands]. The following page contains interesting information on the relation of 1E6E with [Cytochrome p450]. Active as [[1]], with EC number [1.18.1.2]. Full crystallographic information is available from [OCA].

Reference

Adrenodoxin reductase-adrenodoxin complex structure suggests electron transfer path in steroid biosynthesis., Muller JJ, Lapko A, Bourenkov G, Ruckpaul K, Heinemann U, J Biol Chem. 2001 Jan 26;276(4):2786-9. Epub 2000 Oct 25. PMID:11053423[[Category: [2fe-2s]ferredoxin]]

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