9gpb

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Image:9gpb.gif

9gpb, resolution 2.9Å

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THE ALLOSTERIC TRANSITION OF GLYCOGEN PHOSPHORYLASE

Overview

The crystal structure of R-state glycogen phosphorylase b has been, determined at 2.9 A resolution. A comparison of T-state and R-state, structures of the enzyme explains its cooperative behaviour on ligand, binding and the allosteric regulation of its activity. Communication, between catalytic sites of the dimer is provided by a change in packing, geometry of two helices linking each site with the subunit interface., Activation by AMP or by phosphorylation results in a quaternary, conformational change that switches these two helices into the R-state, conformation.

About this Structure

9GPB is a Single protein structure of sequence from Oryctolagus cuniculus with SO4 and PLP as ligands. Active as Phosphorylase, with EC number 2.4.1.1 Full crystallographic information is available from OCA.

Reference

The allosteric transition of glycogen phosphorylase., Barford D, Johnson LN, Nature. 1989 Aug 24;340(6235):609-16. PMID:2770867

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