1d9k

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spinqualitylabelsall models 1d9k, resolution 3.2Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

CRYSTAL STRUCTURE OF COMPLEX BETWEEN D10 TCR AND PMHC I-AK/CA

Overview

The crystal structure of a complex involving the D10 T cell receptor, (TCR), 16-residue foreign peptide antigen, and the I-Ak self major, histocompatibility complex (MHC) class II molecule is reported at 3.2, angstrom resolution. The D10 TCR is oriented in an orthogonal mode, relative to its peptide-MHC (pMHC) ligand, necessitated by the, amino-terminal extension of peptide residues projecting from the MHC class, II antigen-binding groove as part of a mini beta sheet. Consequently, the, disposition of D10 complementarity-determining region loops is altered, relative to that of most pMHCI-specific TCRs; the latter TCRs assume a, diagonal orientation, although with substantial variability. Peptide, recognition, which involves P-1 to P8 residues, is dominated by the Valpha, domain, which also binds to the class II MHC beta1 helix. That docking is, limited to one segment of MHC-bound peptide offers an explanation for, epitope recognition and altered peptide ligand effects, suggests a, structural basis for alloreactivity, and illustrates how bacterial, superantigens can span the TCR-pMHCII surface.

About this Structure

1D9K is a Protein complex structure of sequences from Mus musculus with NDG as ligand. Full crystallographic information is available from OCA.

Reference

The crystal structure of a T cell receptor in complex with peptide and MHC class II., Reinherz EL, Tan K, Tang L, Kern P, Liu J, Xiong Y, Hussey RE, Smolyar A, Hare B, Zhang R, Joachimiak A, Chang HC, Wagner G, Wang J, Science. 1999 Dec 3;286(5446):1913-21. PMID:10583947

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