2bsy

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spinqualitylabelsall models 2bsy, resolution 1.50Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

EPSTEIN BARR VIRUS DUTPASE

Overview

Deoxyuridine 5'-triphosphate pyrophosphatases (dUTPases) are ubiquitous, enzymes cleaving dUTP into dUMP and pyrophosphate. They occur as, monomeric, dimeric, or trimeric molecules. The trimeric and monomeric, enzymes both contain the same five characteristic sequence motifs but in a, different order, whereas the dimeric enzymes are not homologous. Monomeric, dUTPases only occur in herpesviruses, such as Epstein-Barr virus (EBV)., Here, we describe the crystal structures of EBV dUTPase in complex with, the product dUMP and a substrate analog alpha,beta-imino-dUTP. The, molecule consists of three domains forming one active site that has a, structure extremely similar to one of the three active sites of trimeric, dUTPases. The three domains functionally correspond to the subunits of the, ... [(full description)]

About this Structure

2BSY is a [Single protein] structure of sequence from [Epstein-barr virus] with SO4 and UMP as [ligands]. Active as [[1]], with EC number [3.6.1.23]. Full crystallographic information is available from [OCA].

Reference

The monomeric dUTPase from Epstein-Barr virus mimics trimeric dUTPases., Tarbouriech N, Buisson M, Seigneurin JM, Cusack S, Burmeister WP, Structure. 2005 Sep;13(9):1299-310. PMID:16154087

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