1dde

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spinqualitylabelsall models 1dde, resolution 1.7Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

STRUCTURE OF THE DNAG CATALYTIC CORE

Overview

All cellular organisms use specialized RNA polymerases called "primases", to synthesize RNA primers for the initiation of DNA replication. The, high-resolution crystal structure of a primase, comprising the catalytic, core of the Escherichia coli DnaG protein, was determined. The core, structure contains an active-site architecture that is unrelated to other, DNA or RNA polymerase palm folds, but is instead related to the "toprim", fold. On the basis of the structure, it is likely that DnaG binds nucleic, acid in a groove clustered with invariant residues and that DnaG is, positioned within the replisome to accept single-stranded DNA directly, from the replicative helicase.

About this Structure

1DDE is a Single protein structure of sequence from Escherichia coli with Y1 as ligand. Full crystallographic information is available from OCA.

Reference

Structure of the RNA polymerase domain of E. coli primase., Keck JL, Roche DD, Lynch AS, Berger JM, Science. 2000 Mar 31;287(5462):2482-6. PMID:10741967

Page seeded by OCA on Tue Nov 20 13:11:34 2007