We apologize for Proteopedia being slow to respond. For the past two years, a new implementation of Proteopedia has been being built. Soon, it will replace this 18-year old system. All existing content will be moved to the new system at a date that will be announced here.

1dn1

From Proteopedia

Revision as of 11:18, 20 November 2007 by OCA (Talk | contribs)
(diff) ←Older revision | Current revision (diff) | Newer revision→ (diff)
Jump to: navigation, search
Image:1dn1.jpg

1dn1, resolution 2.60Å

Drag the structure with the mouse to rotate

CRYSTAL STRUCTURE OF THE NEURONAL-SEC1/SYNTAXIN 1A COMPLEX

Overview

Syntaxin 1a and neuronal Sec1 (nSec1) form an evolutionarily conserved, heterodimer that is essential for vesicle trafficking and membrane fusion., The crystal structure of the nSec1-syntaxin 1a complex, determined at 2.6, A resolution, reveals that major conformational rearrangements occur in, syntaxin relative to both the core SNARE complex and isolated syntaxin. We, identify regions of the two proteins that seem to determine the binding, specificity of particular Sec1 proteins for syntaxin isoforms, which is, likely to be important for the fidelity of membrane trafficking. The, structure also indicates mechanisms that might couple the action of, upstream effector proteins to conformational changes in syntaxin 1a and, nSec1 that lead to core complex formation and membrane fusion.

About this Structure

1DN1 is a Protein complex structure of sequences from Rattus norvegicus. Full crystallographic information is available from OCA.

Reference

Three-dimensional structure of the neuronal-Sec1-syntaxin 1a complex., Misura KM, Scheller RH, Weis WI, Nature. 2000 Mar 23;404(6776):355-62. PMID:10746715

Page seeded by OCA on Tue Nov 20 13:25:32 2007

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1dn1"
Personal tools