1dqe
From Proteopedia
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BOMBYX MORI PHEROMONE BINDING PROTEIN
Overview
BACKGROUND: Insects use volatile organic molecules to communicate messages, with remarkable sensitivity and specificity. In one of the most studied, systems, female silkworm moths (Bombyx mori) attract male mates with the, pheromone bombykol, a volatile 16-carbon alcohol. In the male moth's, antennae, a pheromone-binding protein conveys bombykol to a membrane-bound, receptor on a nerve cell. The structure of the pheromone-binding protein, its binding and recognition of bombykol, and its full role in signal, transduction are not known. RESULTS: The three-dimensional structure of, the B. mori pheromone-binding protein with bound bombykol has been, determined by X-ray diffraction at 1.8 A resolution. CONCLUSIONS: The, pheromone binding protein of B. mori has six helices, and bombykol binds, in a completely enclosed hydrophobic cavity formed by four antiparallel, helices. Bombykol is bound in this cavity through numerous hydrophobic, interactions, and sequence alignments suggest critical residues for, specific pheromone binding.
About this Structure
1DQE is a Single protein structure of sequence from Bombyx mori with BOM as ligand. Full crystallographic information is available from OCA.
Reference
Sexual attraction in the silkworm moth: structure of the pheromone-binding-protein-bombykol complex., Sandler BH, Nikonova L, Leal WS, Clardy J, Chem Biol. 2000 Feb;7(2):143-51. PMID:10662696
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