1enz

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Image:1enz.gif

1enz, resolution 2.7Å

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CRYSTAL STRUCTURE AND FUNCTION OF THE ISONIAZID TARGET OF MYCOBACTERIUM TUBERCULOSIS

Overview

Resistance to isoniazid in Mycobacterium tuberculosis can be mediated by, substitution of alanine for serine 94 in the InhA protein, the drug's, primary target. InhA was shown to catalyze the beta-nicotinamide adenine, dinucleotide (NADH)-specific reduction of 2-trans-enoyl-acyl carrier, protein, an essential step in fatty acid elongation. Kinetic analyses, suggested that isoniazid resistance is due to a decreased affinity of the, mutant protein for NADH. The three-dimensional structures of wild-type and, mutant InhA, refined to 2.2 and 2.7 angstroms, respectively, revealed that, drug resistance is directly related to a perturbation in the, hydrogen-bonding network that stabilizes NADH binding.

About this Structure

1ENZ is a Single protein structure of sequence from Mycobacterium tuberculosis with NAD as ligand. Full crystallographic information is available from OCA.

Reference

Crystal structure and function of the isoniazid target of Mycobacterium tuberculosis., Dessen A, Quemard A, Blanchard JS, Jacobs WR Jr, Sacchettini JC, Science. 1995 Mar 17;267(5204):1638-41. PMID:7886450

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