1gpf

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spinqualitylabelsall models 1gpf, resolution 1.85Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

CHITINASE B FROM SERRATIA MARCESCENS IN COMPLEX WITH INHIBITOR PSAMMAPLIN

Overview

Several brominated tyrosine derived compounds, psammaplins A (1), K (2), and L (3) as well as bisaprasin (4) were isolated from the Fijian marine, sponge Aplysinella rhax during a bioassay guided isolation protocol. Their, structures were determined using NMR and MS techniques. Psammaplin A was, found to moderately inhibit chitinase B from Serratia marcescens, the mode, of inhibition being non-competitive. Crystallographic studies suggest that, a disordered psammaplin A molecule is bound near the active site., Interestingly, psammaplin A was found to be a potent antifungal agent.

About this Structure

1GPF is a [Single protein] structure of sequence from [Serratia marcescens] with SO4 as [ligand]. Active as [[1]], with EC number [3.2.1.14]. Full crystallographic information is available from [OCA].

Reference

Psammaplin A, a chitinase inhibitor isolated from the Fijian marine sponge Aplysinella rhax., Tabudravu JN, Eijsink VG, Gooday GW, Jaspars M, Komander D, Legg M, Synstad B, van Aalten DM, Bioorg Med Chem. 2002 Apr;10(4):1123-8. PMID:11836123

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