2iyg
From Proteopedia
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DARK STATE STRUCTURE OF THE BLUF DOMAIN OF THE RHODOBACTERIAL PROTEIN APPA
Overview
Proteins containing a sensor of blue light using FAD (BLUF) domain control, diverse cellular processes, such as gene expression, nucleotide metabolism, and motility, by relaying blue light signals to distinct output units., Despite its crucial and widespread functions, the mechanism of BLUF signal, transduction has remained elusive. We determined crystal structures of the, dark-adapted state and of a photo-excited, red-shifted photocycle, intermediate of the BLUF unit of AppA, a purple bacterial photoreceptor, involved in the light-dependent regulation of photosynthesis gene, expression. In contrast to a recently published crystal structure of the, AppA BLUF domain determined in the presence of detergent molecules, our, structural model of the dark state corresponds well to those reported ... [(full description)]
About this Structure
2IYG is a [Single protein] structure of sequence from [Rhodobacter sphaeroides] with FMN, DTU and DTT as [ligands]. Full crystallographic information is available from [OCA].
Reference
Crystal structures of the AppA BLUF domain photoreceptor provide insights into blue light-mediated signal transduction., Jung A, Reinstein J, Domratcheva T, Shoeman RL, Schlichting I, J Mol Biol. 2006 Sep 29;362(4):717-32. Epub 2006 Jul 15. PMID:16949615
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