1gsk

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spinqualitylabelsall models 1gsk, resolution 1.70Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

CRYSTAL STRUCTURE OF COTA, AN ENDOSPORE COAT PROTEIN FROM BACILLUS SUBTILIS

Overview

Endospores produced by the Gram-positive soil bacterium Bacillus subtilis, are shielded by a proteinaceous coat formed by over 30 structural, components, which self-assemble into a lamellar inner coat and a thicker, striated electrodense outer coat. The 65-kDa CotA protein is an abundant, component of the outer coat layer. CotA is a highly thermostable laccase, assembly of which into the coat is required for spore resistance against, hydrogen peroxide and UV light. Here, we report the structure of CotA at, 1.7-A resolution, as determined by x-ray crystallography. This is the, first structure of an endospore coat component, and also the first, structure of a bacterial laccase. The overall fold of CotA comprises three, cupredoxin-like domains and includes one mononuclear and one trinuclear, ... [(full description)]

About this Structure

1GSK is a [Single protein] structure of sequence from [Bacillus subtilis] with CU, C2O, C1O and GOL as [ligands]. Full crystallographic information is available from [OCA].

Reference

Crystal structure of a bacterial endospore coat component. A laccase with enhanced thermostability properties., Enguita FJ, Martins LO, Henriques AO, Carrondo MA, J Biol Chem. 2003 May 23;278(21):19416-25. Epub 2003 Mar 13. PMID:12637519

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