1gj4
From Proteopedia
SELECTIVITY AT S1, H2O DISPLACEMENT, UPA, TPA, SER190/ALA190 PROTEASE, STRUCTURE-BASED DRUG DESIGN
Template:ABSTRACT PUBMED 11731301
About this Structure
1GJ4 is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Engineering inhibitors highly selective for the S1 sites of Ser190 trypsin-like serine protease drug targets., Katz BA, Sprengeler PA, Luong C, Verner E, Elrod K, Kirtley M, Janc J, Spencer JR, Breitenbucher JG, Hui H, McGee D, Allen D, Martelli A, Mackman RL, Chem Biol. 2001 Nov;8(11):1107-21. PMID:11731301
Page seeded by OCA on Tue Jul 1 05:22:18 2008
Categories: Homo sapiens | Protein complex | Thrombin | Allen, D. | Breitenbucher, J G. | Hui, H. | Katz, B A. | Luong, C. | Mackman, R L. | Martelli, A. | McGee, D. | Spencer, J R. | Sprengeler, P A. | Verner, E. | Oxyanion hole water | Shift of pka of his57 | Specificity | Structure-based drug design | Three-centered | Trypsin | Urokinase | Very short hydrogen bond | Zn+2-mediated inhibition
