1gsy
From Proteopedia
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GLUTATHIONE S-TRANSFERASE YFYF, CLASS PI, COMPLEXED WITH GLUTATHIONE
Overview
The three-dimensional crystal structure of pi class glutathione, S-transferase YfYf from mouse liver complexed with the inhibitor, S-(p-nitrobenzyl)glutathione has been determined at 1.8 A resolution by, X-ray diffraction. In addition two complexes with glutathione sulphonic, acid and S-hexylglutathione have been determined at resolutions of 1.9 and, 2.2 A, respectively. The high resolution of the, S-(p-nitrobenzyl)glutathione complex allows a detailed analysis of the, active site including the hydrophobic (H-) subsite. The nitrobenzyl moiety, occupies a hydrophobic pocket with its aromatic ring sandwiched between, Phe8 and the hydroxyl group of Tyr108. An insertion of two residues Gly41, and Leu42, with respect to the pig enzyme, splits helix alpha B into an, alpha-helix and a 3(10) ... [(full description)]
About this Structure
1GSY is a [Single protein] structure of sequence from [Mus musculus] with GTT as [ligand]. Active as [[1]], with EC number [2.5.1.18]. Full crystallographic information is available from [OCA].
Reference
Molecular structure at 1.8 A of mouse liver class pi glutathione S-transferase complexed with S-(p-nitrobenzyl)glutathione and other inhibitors., Garcia-Saez I, Parraga A, Phillips MF, Mantle TJ, Coll M, J Mol Biol. 1994 Apr 1;237(3):298-314. PMID:8145243
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