1g7p
From Proteopedia
|
CRYSTAL STRUCTURE OF MHC CLASS I H-2KB HEAVY CHAIN COMPLEXED WITH BETA-2 MICROGLOBULIN AND YEAST ALPHA-GLUCOSIDASE
Overview
The crystal structure of a non-standard peptide, YEA9, in complex with, H-2Kb, at 1.5 A resolution demonstrates how YEA9 peptide can bind with, surprisingly high affinity through insertion of alternative, long, non-canonical anchors into the B and E pockets. The use of "alternative, pockets" represents a new mode of high affinity peptide binding, that, should be considered when predicting peptide epitopes for MHC class I., These novel interactions encountered in this non-canonical high affinity, peptide-MHC complex should help predict additional binding peptides from, primary protein sequences and aid in the design of alternative approaches, for peptide-based vaccines.
About this Structure
1G7P is a Protein complex structure of sequences from Mus musculus with NAG as ligand. Active as Alpha-glucosidase, with EC number 3.2.1.20 Full crystallographic information is available from OCA.
Reference
Crystal structure of a non-canonical high affinity peptide complexed with MHC class I: a novel use of alternative anchors., Apostolopoulos V, Yu M, Corper AL, Li W, McKenzie IF, Teyton L, Wilson IA, Plebanski M, J Mol Biol. 2002 May 17;318(5):1307-16. PMID:12083519
Page seeded by OCA on Tue Nov 20 15:47:19 2007
Categories: Alpha-glucosidase | Mus musculus | Protein complex | Apostolopoulos, V. | Corper, A.L. | Li, W. | McKenzie, I.F. | Teyton, L. | Wilson, I.A. | Yu, M. | NAG | H-2kb | Mhc class i | S. cerevisiae | Yeast
