This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
1w1w
From Proteopedia
|
SC SMC1HD:SCC1-C COMPLEX, ATPGS
Overview
A multisubunit complex called cohesin forms a huge ring structure that, mediates sister chromatid cohesion, possibly by entrapping sister DNAs, following replication. Cohesin's kleisin subunit Scc1 completes the ring, connecting the ABC-like ATPase heads of a V-shaped Smc1/3 heterodimer., Proteolytic cleavage of Scc1 by separase triggers sister chromatid, disjunction, presumably by breaking the Scc1 bridge. One half of the, SMC-kleisin bridge is revealed here by a crystal structure of Smc1's, ATPase complexed with Scc1's C-terminal domain. The latter forms a winged, helix that binds a pair of beta strands in Smc1's ATPase head. Mutation of, conserved residues within the contact interface destroys Scc1's, interaction with Smc1/3 heterodimers and eliminates cohesin function., Interaction of ... [(full description)]
About this Structure
1W1W is a [Protein complex] structure of sequences from [Saccharomyces cerevisiae] with MG and ATG as [ligands]. Full crystallographic information is available from [OCA].
Reference
Structure and stability of cohesin's Smc1-kleisin interaction., Haering CH, Schoffnegger D, Nishino T, Helmhart W, Nasmyth K, Lowe J, Mol Cell. 2004 Sep 24;15(6):951-64. PMID:15383284
Page seeded by OCA on Mon Oct 29 19:56:04 2007
Categories: Protein complex | Saccharomyces cerevisiae | Haering, C. | Lowe, J. | Nasmyth, K. | ATG | MG | Abc atpase | Cell cycle | Chromosome segregation | Cohesin | Dimer | Kleisin | Mitosis
