2bq1

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spinqualitylabelsall models 2bq1, resolution 3.99Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

RIBONUCLEOTIDE REDUCTASE CLASS 1B HOLOCOMPLEX R1E,R2F FROM SALMONELLA TYPHIMURIUM

Overview

Ribonucleotide reductase is an indispensable enzyme for all cells, since, it catalyses the biosynthesis of the precursors necessary for both, building and repairing DNA. The ribonucleotide reductase class I enzymes, present in all mammals as well as in many prokaryotes and DNA viruses, are, composed mostly of two homodimeric proteins, R1 and R2. The reaction, involves long-range radical transfer between the two proteins. Here, we, present the first crystal structure of a ribonucleotide reductase R1/R2, holocomplex. The biological relevance of this complex is based on the, binding of the R2 C terminus in the hydrophobic cleft of R1, an, interaction proven to be crucial for enzyme activity, and by the fact that, all conserved amino acid residues in R2 are facing the R1 active sites. We, ... [(full description)]

About this Structure

2BQ1 is a [Protein complex] structure of sequences from [Salmonella typhimurium] with MG, FE and DGT as [ligands]. Active as [[1]], with EC number [1.17.4.1]. Full crystallographic information is available from [OCA].

Reference

The first holocomplex structure of ribonucleotide reductase gives new insight into its mechanism of action., Uppsten M, Farnegardh M, Domkin V, Uhlin U, J Mol Biol. 2006 Jun 2;359(2):365-77. Epub 2006 Mar 31. PMID:16631785

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