1kw0

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Template:STRUCTURE 1kw0

Contents

Catalytic Domain of Human Phenylalanine Hydroxylase (Fe(II)) in Complex with Tetrahydrobiopterin and Thienylalanine

Template:ABSTRACT PUBMED 12126628

Disease

Known disease associated with this structure: Phenylketonuria OMIM:[261600], Hyperphenylalaninemia, mild OMIM:[261600]

About this Structure

1KW0 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of the ternary complex of the catalytic domain of human phenylalanine hydroxylase with tetrahydrobiopterin and 3-(2-thienyl)-L-alanine, and its implications for the mechanism of catalysis and substrate activation., Andersen OA, Flatmark T, Hough E, J Mol Biol. 2002 Jul 26;320(5):1095-108. PMID:12126628

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