3ch6

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Template:STRUCTURE 3ch6

Crystal Structure of 11beta-HSD1 Double Mutant (L262R, F278E) Complexed with (3,3-dimethylpiperidin-1-yl)(6-(3-fluoro-4-methylphenyl)pyridin-2-yl)methanone

Template:ABSTRACT PUBMED 18485702

About this Structure

3CH6 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Pyridine amides as potent and selective inhibitors of 11beta-hydroxysteroid dehydrogenase type 1., Wang H, Ruan Z, Li JJ, Simpkins LM, Smirk RA, Wu SC, Hutchins RD, Nirschl DS, Van Kirk K, Cooper CB, Sutton JC, Ma Z, Golla R, Seethala R, Salyan ME, Nayeem A, Krystek SR Jr, Sheriff S, Camac DM, Morin PE, Carpenter B, Robl JA, Zahler R, Gordon DA, Hamann LG, Bioorg Med Chem Lett. 2008 Jun 1;18(11):3168-72. Epub 2008 May 1. PMID:18485702

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