1j90
From Proteopedia
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Crystal Structure of Drosophila Deoxyribonucleoside Kinase
Overview
Deoxyribonucleoside kinases phosphorylate deoxyribonucleosides and, activate a number of medically important nucleoside analogs. Here we, report the structure of the Drosophila deoxyribonucleoside kinase with, deoxycytidine bound at the nucleoside binding site and that of the human, deoxyguanosine kinase with ATP at the nucleoside substrate binding site., Compared to the human kinase, the Drosophila kinase has a wider substrate, cleft, which may be responsible for the broad substrate specificity of, this enzyme. The human deoxyguanosine kinase is highly specific for purine, substrates; this is apparently due to the presence of Arg 118, which, provides favorable hydrogen bonding interactions with the substrate. The, two new structures provide an explanation for the substrate specificity of, cellular deoxyribonucleoside kinases.
About this Structure
1J90 is a Single protein structure of sequence from Drosophila melanogaster with SO4 and DCZ as ligands. Full crystallographic information is available from OCA.
Reference
Structural basis for substrate specificities of cellular deoxyribonucleoside kinases., Johansson K, Ramaswamy S, Ljungcrantz C, Knecht W, Piskur J, Munch-Petersen B, Eriksson S, Eklund H, Nat Struct Biol. 2001 Jul;8(7):616-20. PMID:11427893
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