2c9k
From Proteopedia
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STRUCTURE OF THE FUNCTIONAL FORM OF THE MOSQUITO-LARVICIDAL CRY4AA TOXIN FROM BACILLUS THURINGIENSIS AT 2.8 A RESOLUTION
Overview
The Cry4Aa delta-endotoxin from Bacillus thuringiensis is toxic to larvae, of Culex, Anopheles, and Aedes mosquitoes, which are vectors of important, human tropical diseases. With the objective of designing modified toxins, with improved potency that could be used as biopesticides, we determined, the structure of this toxin in its functional form at a resolution of 2.8, angstroms. Like other Cry delta-endotoxins, the activated Cry4Aa toxin, consists of three globular domains, a seven-alpha-helix bundle responsible, for pore formation (domain I) and the following two other domains having, structural similarities with carbohydrate binding proteins: a beta-prism, (domain II) and a plant lectin-like beta-sandwich (domain III). We also, studied the effect on toxicity of amino acid ... [(full description)]
About this Structure
2C9K is a [Single protein] structure of sequence from [Bacillus thuringiensis] with MPD as [ligand]. Full crystallographic information is available from [OCA].
Reference
Structure of the functional form of the mosquito larvicidal Cry4Aa toxin from Bacillus thuringiensis at a 2.8-angstrom resolution., Boonserm P, Mo M, Angsuthanasombat C, Lescar J, J Bacteriol. 2006 May;188(9):3391-401. PMID:16621834
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