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1jeo
From Proteopedia
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Crystal Structure of the Hypothetical Protein MJ1247 from Methanococcus jannaschii at 2.0 A Resolution Infers a Molecular Function of 3-Hexulose-6-Phosphate isomerase.
Overview
The crystal structure of the hypothetical protein MJ1247 from, Methanococccus jannaschii at 2 A resolution, a detailed sequence analysis, and biochemical assays infer its molecular function to be, 3-hexulose-6-phosphate isomerase (PHI). In the dissimilatory ribulose, monophosphate (RuMP) cycle, ribulose-5-phosphate is coupled to, formaldehyde by the 3-hexulose-6-phosphate synthase (HPS), yielding, hexulose-6-phosphate, which is then isomerized to fructose-6-phosphate by, the enzyme 3-hexulose-6-phosphate isomerase. MJ1247 is an alpha/beta, structure consisting of a five-stranded parallel beta sheet flanked on, both sides by alpha helices, forming a three-layered alpha-beta-alpha, sandwich. The fold represents the nucleotide binding motif of a flavodoxin, type. MJ1247 is a tetramer in the crystal and in solution and each monomer, has a folding similar to the isomerase domain of glucosamine-6-phosphate, synthase (GlmS).
About this Structure
1JEO is a Single protein structure of sequence from Methanocaldococcus jannaschii with CIT as ligand. Full crystallographic information is available from OCA.
Reference
Crystal structure of MJ1247 protein from M. jannaschii at 2.0 A resolution infers a molecular function of 3-hexulose-6-phosphate isomerase., Martinez-Cruz LA, Dreyer MK, Boisvert DC, Yokota H, Martinez-Chantar ML, Kim R, Kim SH, Structure. 2002 Feb;10(2):195-204. PMID:11839305
Page seeded by OCA on Tue Nov 20 18:10:19 2007
Categories: Methanocaldococcus jannaschii | Single protein | BSGC, Berkeley.Structural.Genomics.Center. | Boisvert, D.C. | Dreyer, M.K. | Kim, R. | Kim, S.H. | Martinez-Chantar, M.L. | Martinez-Cruz, L.A. | Yokota, H. | CIT | 3-hexulose-6-phosphate isomerase | Berkeley structural genomics center | Bsgc structure funded by nih | Phi | Phosphosugar | Protein structure initiative | Psi | Rump pathway | Structural genomics
