1jmm
From Proteopedia
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Crystal structure of the V-region of Streptococcus mutans antigen I/II
Overview
Antigens I/II are large multifunctional adhesins from oral viridans, streptococci that exert immunomodulatory effects on human cells and play, important roles in inflammatory disorders. Among them, Streptococcus, mutans plays a major role in the initiation of dental caries. The, structure of the V-region (SrV+, residues 464-840) of the antigen I/II of, S. mutans has been determined using the multiwavelength anomalous, diffraction phasing technique with seleno-methionine-substituted, recombinant protein and subsequently refined at 2.4 A resolution. The, crystal structure of SrV+ revealed a lectin-like fold that displays a, putative preformed carbohydrate-binding site stabilized by a metal ion., Inhibition of this binding site may confer to humans a protection against, dental caries and dissemination of the bacteria to extra-oral sites, involved in life-threatening inflammatory diseases. This crystal structure, constitutes a first step in understanding the structure-function, relationship of antigens I/II and may help in delineating new preventive, or therapeutic strategies against colonization of the host by oral, streptococci.
About this Structure
1JMM is a Single protein structure of sequence from Streptococcus mutans with NA as ligand. Full crystallographic information is available from OCA.
Reference
Crystal structure of the V-region of Streptococcus mutans antigen I/II at 2.4 A resolution suggests a sugar preformed binding site., Troffer-Charlier N, Ogier J, Moras D, Cavarelli J, J Mol Biol. 2002 Apr 19;318(1):179-88. PMID:12054777
Page seeded by OCA on Tue Nov 20 18:22:51 2007
