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1sa4
From Proteopedia
human protein farnesyltransferase complexed with FPP and R115777
Template:ABSTRACT PUBMED 15170324
About this Structure
1SA4 is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Crystal structures of the anticancer clinical candidates R115777 (Tipifarnib) and BMS-214662 complexed with protein farnesyltransferase suggest a mechanism of FTI selectivity., Reid TS, Beese LS, Biochemistry. 2004 Jun 8;43(22):6877-84. PMID:15170324
Page seeded by OCA on Sun Jul 27 12:17:55 2008
Categories: Homo sapiens | Protein complex | Protein farnesyltransferase | Beese, L S. | Reid, T S. | Caax | Cancer | Clinical candidate | Farnesyl transferase | Farnesyltransferase | Ftase | Fti | Inhibitor | Lipid modification | Protein prenylation | R115777 | Ra | Tipifarnib | Tumor regression | Zarnestra
