1jxo
From Proteopedia
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Crystal Structure of the SH3-HOOK-GK Fragment of PSD-95
Overview
PSD-95/SAP90 is a member of the MAGUK superfamily. In excitatory synapses, PSD-95 clusters receptors and ion channels at specific sites in the, postsynaptic membrane and organizes downstream signaling and cytoskeletal, molecules. We have determined the crystal structures of the apo and, GMP-bound forms to 2.3 and 2.0 A resolutions, respectively, of a fragment, containing the SH3, HOOK, and guanylate kinase (GK) domains of PSD-95. We, observe an intramolecular interaction between the SH3 and GK domains, involving the formation of a beta sheet including residues N- and, C-terminal to the GK domain. Based on amino acid conservation and, mutational data available in the literature, we propose that this, intramolecular interaction is a common feature among MAGUK proteins.
About this Structure
1JXO is a Single protein structure of sequence from Rattus norvegicus. Full crystallographic information is available from OCA.
Reference
Structural characterization of the intramolecular interaction between the SH3 and guanylate kinase domains of PSD-95., Tavares GA, Panepucci EH, Brunger AT, Mol Cell. 2001 Dec;8(6):1313-25. PMID:11779506
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